Biosynthetically Inspired Syntheses of Secu′amamine A and Fluvirosaones A and B

Sanghyeon Lee, Gyumin Kang, Garam Chung, Dongwook Kim, Hee‐Yoon Lee and Sunkyu Han, Angew. Chem. Int. Ed., 59, 6894.

Au(I)-Catalyzed Cyclization of Epoxyalkynes to Allylic Alcohol Containing Spiroketals and Application to the Total Synthesis of (−)-Alotaketal A

Jaeyeon Lee, Jiheon Kim, and Hee-Yoon Lee, Org. Lett., 22, 

Unexpected Selectivity of Intramolecular [3+2] Cycloaddition of Trimethylenemethane (TMM) Diyl toward Total Synthesis of Conidiogenone B

Myungjo J. Kim, Sanghyeon Lee, Taek Kang, Mu-Hyun Baik, and Hee-Yoon Lee, Eur. J. Org. Chem., 2020, 609.

Pharmaceutical Composition, Containing Nm23 Activator, for Inhibiting Cancer Metastasis

Kong Joo Lee, Hee-Yoon Lee, Je Jin Lee, Eun-Kyoung Seo, Eun Sun Lee, Hwang Suk Kim, Hongsoo Lee, US Pat. Appl., US20200078319A1.



Synthetic Strategies for (−)‐Cannabidiol and Its Structural Analogs

Byunghyuck Jung, Jungkyu K. Lee, Jungnam Kim, Eunhye K. Kang, Sang Yeong Han, Hee-Yoon Lee, and Insung S. Choi, Chemistry - An Asian Journal, 14, 3749.





A Carbon Dioxide-Catalyzed Stereoselective Cyanation Reaction

Tamal Roy, Myungjo J. Kim, Yang Yang, Suyeon Kim, Gyumin Kang, Xinyi Ren, Anders Kadziola, Hee-Yoon Lee, Mu-Hyun Baik, and Ji-Woong Lee, ACS Catalysis, 9, 6006. [Supplementary Cover]

Cu(OTf)2-Promoted 1,4-Addition of Alkyl Bromides to Dehydroalanine

Jung-Ah Shin, Jiheon Kim, Hongsoo Lee, Sura Ha, and Hee-Yoon Lee, J. Org. Chem., 84, 4558

Aldehyde Carboxylation: A Concise DFT Mechanistic Study and a Hypothetical Role of CO2 in the Origin of Life

Martin Juhl, Myungjo J. Kim, Hee-Yoon Lee, Mu-Hyun Baik, and Ji-Woong Lee, Synlett, 30, 987.




(+)-Dimericbiscognienyne A: Total Synthesis and Mechanistic Investigations of the Key Heterodimerization

Geon Kim, Myungjo J. Kim, Garam Chung, Hee-Yoon Lee, and Sunkyu Han, Organic Letters, 20, 6886

Small molecule activator of Nm23/NDPK as an inhibitor of metastasis

Jae-Jin Lee, Hwang Suk Kim, Ji-Sun Lee, Jimin Park, SangChul Shin, Soonwha Song, Eunsun Lee, Jung-EunChoi, Ji-Wan Suh, Hongsoo Lee, Eunice EunKyeong Kim, Eun Kyoung Seo, Dong Hae Shin, Ho-Young Lee, Hee-Yoon Lee & Kong-Joo Lee, Scientific Reports, 8, 10909


A formal total synthesis of (+)-Frondosin A

Kwon, K; Ham, JS; Kim, HY; Sampath, V; Lee, H-Y, Asian Journal of Organic Chemistry, 6, 1594

Total Synthesis of (±)-Waihoensene.

Lee, HS; Kang, T; Lee, H-Y, Angewandte Chemie International Edition, 56, 8254

Total Synthesis of (−)-Phorbaketal A

Joung, SW; Kim, RR; Lee, H-Y, Organic Letters, 19, 3903

An efficient Cu-catalyzed azide–alkyne cycloaddition (CuAAC) reaction in aqueous medium with a zwitterionic ligand, betaine

Shin, J-A; Oh, S-J; Lee, H-Y; Lim, Y-G, Catalysis Science & Technology, 7, 2450 [Front Cover]

Active maintenance of endothelial cells prevents kidney fibrosis

Yang, SH; Kim, YC; An, JN; Kim, JH; Lee, J; Lee, H-Y; Cho, J-Y; Paik, JH; Oh, YK; Lim, CS; Kim, YS; Lee, JP, Kidney Research and Clinical Practice, 36, 329


A chemical biology route to site-specific authentic protein modifications.

Yang, A; Ha, S; Ahn, J; Kim, R; Kim, S; Lee, Y; Kim, J; Söll, D; Lee, HY; Park, HS, Science, 354, 623

Synthesis and Biological Evaluation of Substituted PyrazoleConstrained Piperazine Derivative Library for Dopamine ReceptorAntagonist

Kamalkishor P. Landge; Hyun Ju Song; Jung Gook Lee; Sang Eun Chae; Ae Nim Pae; Woo Kyu Park; Vasu Sampath; Hee Yoon Lee; Hun Yeong Ko, Bull. Kor. Chem. Soc., 37, 2076





Trimethylenemethane diyl mediated tandem cycloaddition reactions: mechanism based design of synthetic strategies.

Lee HY, Acc. Chem. Res.,48(8), 2308-19

ROSics: Chemistry and proteomics of cysteine modifications in redox biology. 

Kim, Hee-Jung; Ha, Sura; Lee, Hee-Yoon; Lee, Kong-Joo, Mass Spectrometry Reviews, 34(2), 184-208.


Tissue-based metabolic labeling of polysialic acids in living primary hippocampal neurons. 
Kang, Kyungtae; Joo, Sunghoon; Choi, Ji Yu; Geum, Sujeong; Hong, Seok-Pyo; Lee, Seung-Yeul; Kim, Yong Ho; Kim, Seong-Min; Yoon, Myung-Han; Nam, Yoonkey; Lee, Kyung-Bok; Lee, Hee-Yoon; Choi, Insung S., Proceedings of the National Academy of Sciences of the United States of America, 112(3), E241-E248.




Sulfhydryl-Specific Probe for Monitoring Protein Redox Sensitivity. 
Lee, Jae-Jin; Ha, Sura; Kim, Hee-Jung; Ha, Hyun Joo; Lee, Hee-Yoon; Lee, Kong-Joo, ACS Chemical Biology, 9(12), 2883-2894.

Total synthesis of (-)-crinipellin A. 
Taek Kang; Seog Boem Song; Won-Yeob Kim; Byung Gyu Kim; Hee-Yoon Lee, Journal of the American Chemical Society, 136, 10274-10276.

Total synthesis of panaginsene with structural revision. 
Sujeong Geum; Hee-Yoon Lee, Organic Letters, 16, 2466-2469.

Total Synthesis of the Crinipellins. 
Kang, Taek; Lee, Hee-Yoon, Strategies and Tactics in Organic Synthesis, 10, 271-291.


Preparation of benzene derivatives as UCH-L1 inhibitors.
Lee, Kong-Joo; Kim, Youhwa; Kim, Hyun Jung; Lee, Hee-Yoon; Joung, Seewon; Jeong, Jae Eun; Seo, Eun-Kyoung, PCT Int. Appl., WO 2014185561 A1 20141120.


Stereospecific mechanism of DJ-1 glyoxalases inferred from their hemithiacetal-containing crystal structures. 
Choi, Dongwook; Kim, Jihong; Ha, Sura; Kwon, Kyu; Kim, Eun-Hee; Lee, Hee-Yoon; Ryu, Kyoung-Seok; Park, Chankyu, The FEBS Journal, 281(24), 5447-62.

Regioselective Click Chemistry for Construction of Arylpiperazinyl 1,2,3-Triazole Derivative Libraries as Dopamine D4/D3 Receptor Ligands

Ju Myung Kwak; Ji Su Moon; Sangei Seo; Jea I Choi; Vasu Sampath; Hee-Yoon Lee; Hun Yeong Koh, Bull. Kor. Chem. Soc., 35, 3675




CP-690550 Treatment Ameliorates Established Disease and Provides Long-Term Therapeutic Effects in an SKG Arthritis Model.

Oh K; Seo MW; Kim IG; Hwang YI; Lee HY; Lee DS, Immune Netw., 13, 257-263.

Correlation between Functionality Preference of Ru Carbenes and exo/endo Product Selectivity for Clarifying the Mechanism of Ring-Closing Enyne Metathesis. 
Lee, Ok Suk; Kim, Kyung Hwan; Kim, Jinwoo; Kwon, Kuktae; Ok, Taedong; Ihee, Hyotcherl; Lee, Hee-Yoon; Sohn, Jeong-Hun. Journal of Organic Chemistry, 78, 8242-8249.


Chemical Control of Yeast Cell Division by Cross-Linked Shells of Catechol-Grafted Polyelectrolyte Multilayers. 
Lee, Juno; Yang, Sung Ho; Hong, Seok-Pyo; Hong, Daewha; Lee, Haeshin; Lee, Hee-Yoon; Kim, Yang-Gyun; Choi, Insung S. Macromolecular Rapid Communications, 34, 1351-1356.


An asymmetric total synthesis of (+)-pentalenene. 
Kim, Yoon-Jung; Yoon, Yeokwon; Lee, Hee-Yoon. Tetrahedron, 69, 7810-7816.


Aziridinyl imines in organic synthesis: development of tandem reaction strategies and application to total synthesis of natural products. 
Lee, Hee-Yoon; Song, Seog-Beom; Kang, Taek; Kim, Yoon Jung; Geum, Su Jeong; IUPAC Commission. Pure and Applied Chemistry, 85, 741-753.





Total Synthesis of Ceratopicanol through Tandem Cycloaddition Reaction of a Linear Substrate. 
Lee, Sang-Shin; Kim, Won-Yeob; Lee, Hee-Yoon. Chemistry - An Asian Journal (2012), 7, 2450-2456.


A Formal Total Synthesis of Dysiherbaine and Neodysiherbaine. 
Lee, Hee-Yoon; Lee, Sang-Shin; Kim, Hoon Seok; Lee, Kang Mun. European Journal of Organic Chemistry (2012), 22, 4192-4199.


Soluble epoxide hydrolase activity determines the severity of ischemia-reperfusion injury in kidney.

Lee, Jung Pyo; Yang, Seung Hee; Lee, Hee-Yoon; Kim, Bora; Cho, Joo-Youn; Paik, Jin Ho; Oh, Yung Jung; Kim, Dong Ki; Lim, Chun Soo; Kim, Yon Su. PLoS One (2012), 7, e37075.


6-Diazohexa-1,2-diene multi-purpose building blocks of consecutive cyclization.
Gang, Taek; Geum, Su-Jeong; Kim, Yoon-Jung; Lee, Hee-Yoon. Hwahak Sekye (2012), 52, 21-24.


MBIT (Mass Balanced Isotope Tag) labeling agents for performing simultaneous quantitative analysis of multiple proteins and the other biomolecules by mass spectrometry. 
Shin, Seung Koo; Yoon, Hye Joo; Jung, Yong Sik; Lee, Hee-Yoon; Suh, Min Soo; Seo, Jong Cheol. PCT Int. Appl. (2012), WO 2012026743 A2 20120301.





Tandem Cycloaddition Reactions of Allenyl Diazo Compounds Forming Triquinanes via Trimethyleneme-thane Diyls.
Kang, Taek; Kim, Won-Yeob; Yoon, Yeokwon; Kim, Byung Gyu; Lee, Hee-Yoon. Journal of the American Chemical Society (2011), 133(45), 18050-18053


A facile synthesis of (S)-felodipine. 
Kwon, Kuktae; Shin, Jung A.; Lee, Hee-Yoon. Tetrahedron (2011), 67(52), 10222.


Unexpected Formation of a trans-syn-Fused Linear Triquinane from a Trimethylenemethane (TMM)-Diyl-Mediated [2+3] Cycloaddition Reaction. 
Kim, Won-Yeob; Kim, Byung Gyu; Kang, Taek; Lee, Hee-Yoon. Chemistry-An Asian Journal (2011), 6(8), 1931-1935.


Novel oxidative modifications in redox-active cysteine residues. 
Jeong, Jaeho; Jung, Yongsik; Na, Seungjin; Jeong, Jihye; Lee, Eunsun; Kim, Mi-Sun; Choi, Sun; Shin, Dong-Hae; Paek, Eunok; Lee, Hee-Yoon; et al. Molecular and Cellular Proteomics (2011), 10(3), 1-13.


Phorbasones A and B, sesterterpenoids isolated from the marine sponge Phorbas sp. and induction of osteoblast differentiation. 
Rho, Jung-Rae; Hwang, Byung Su; Joung, Seewon; Byun, Mi Ran; Hong, Jeong-Ho; Lee, Hee-Yoon. Organic Letters (2011), 13(5), 884-887.


Stereoselectivity in Trimethylenemethane (TMM) Diyl Mediated Cycloaddition Reaction to Angularly Fused Triquinanes. 
Yoon, Yeo-Kwon; Kang, Taek; Lee, Hee-Yoon. Chemistry-An Asian Journal (2011), 6(2), 646-651.


Identification of substituted pyrazole constrained arylpiperazines as selective ligands for serotonin 5HT1a and 5HT2a receptors. 
Landge, Kamalkishor P.; Kim, Jee Hee; Park, Woo-Kyu; Gong, Jae Yang; Koh, Hun Yeong; Lee, Hee-Yoon. Bulletin of the Korean Chemical Society (2011), 32(8), 2861-2862.


Versatile synthesis of disubstituted triazole library for dopamine and serotonin receptor ligands.
Landge, Kamalkishor P.; Seo, Yong Wan; Kwak, Jumyung; Park, Woo Kyu; Gong, Jae Yang; Lee, Hee-Yoon; Koh, Hun Yeong. Bulletin of the Korean Chemical Society (2011), 32(8), 3101-3104.





CP-690550, a Janus Kinase Inhibitor, Suppresses CD4+ T-Cell-Mediated Acute Graft-Versus-Host Disease by Inhibiting the Interferon-g Pathway. 
Park, Hyung-Bae; Oh, Keunhee; Garmaa, Nandin; Seo, Myung Won; Byoun, Ok-Jin; Lee, Hee-Yoon; Lee, Dong-Sup. Transplantation (2010), 90, 825-835.


Design, synthesis and antiviral activity of 5-hydroxymethyl-3-phosphonyl-4,5-dihydrofuran analogs of nucleotides. 
Lee, Hee-Yoon; Lee, Kiho; Hah, Jung Hwan; Moon, Deuk Kyu; Lee, Chong-Kyo. Bulletin of the Korean Chemical Society (2010), 31, 2139-2140.


Synthesis and pharmacological evaluation of 3-aryl-3-azolylpropan-1-amines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. 
Lee, Ki-Ho; Park, Chun-Eung; Min, Kyung-Hyun; Shin, Yong-Je; Chung, Coo-Min; Kim, Hui-Ho; Yoon, Hae-Jeoung; Won-Kim; Ryu, Eun-Ju; Shin, Yu-Jin; Nam, Hyun-Sik; Cho, Jeong-Woo; Lee, Hee-Yoon. Bioorganic & Medicinal Chemistry Letters (2010), 20, 5567.


Angularly Fused Triquinanes from Linear Substrates through Trimethylenemethane Diyl [2+3] Cycloaddition Reaction. 
Lee, Hee-Yoon; Jung, Yongsik; Yoon, Yeokwon; Kim, Byung Gyu; Kim, Yeonjoon. Org. Lett.(2010), 12, 2672-2674.


Construction of the ABC-ring system of delnudine through free radical cyclization and alkylidene carbene C-H insertion. 
Lee, Sejin; Lee, Hee-Yoon. Bull. Korean. Chem. Soc. (2010), 31(3), 557-558.


A receptor-independent, cell-based JAK activation assay for screening for JAK3-specific inhibitors. 
Oh, Keunhee; Joo, Kyeung Min; Jung, Yong Sik; Lee, Jaehwan; Kang, Heonjoong; Lee, Hee-Yoon; Lee, Dong-Sup. J. Immunological Methods (2010), 354, 45-52.


Process for preparing (S)-(-)-felodipine. 
Auh, Jin; Won, Duk Kwon; Moon, Byung Hyun; Kwon, O. Zoon; Jong, Chang Woo; Jin, Kyung Yong; Bae, Kyoung Ho; Lee, Hee Yoon; Shin, Jung Ah. PCT Int. Appl. (2010), 24pp.





Phorbaketals A, B, and C, Sesterterpenoids with a Spiroketal of Hydrobenzopyran Moiety Isolated from the Marine Sponge Phorbas sp. 
Rho, Jung-Rae; Hwang, Buyng Su; Sim, Chung Ja; Joung, Seewon; Lee, Hee-Yoon; Kim, Hyeon-Jin. Organic Letters (2009), 11, 5590


Anhydrous Hydration of Nitriles to Amides using Aldoximes as the Water Source. 
Lee, Jinwoo; Kim, Min; Chang, Sukbok; Lee, Hee-Yoon. Organic Letters (2009), 11, 5598.


Total Synthesis of (-)-13-Acetoxymodhephene and (+)-14-Acetoxymodhephene. 
Lee, Hee-Yoon; Murugan, Ravichandran N.; Moon, Deuk Kyu. Eur. J. Org. Chem. (2009), 29, 5028.


A new structural class of S-adenosylhomocysteine hydrolase inhibitors. 
Kim, Byung Gyu; Chun, Tae Gyu; Lee, Hee-Yoon; Snapper, Marc L. BMC (2009), 17, 6707-6714.


Significant Self-Acceleration Effects of Nitrile Additives in the Rhodium-Catalyzed Conversion of Aldoximes to Amides: A New Mechanistic Aspect. 
Kim, Min; Lee, Jinwoo; Lee, Hee-Yoon; Chang, Sukbok. Advanced Synthesis & Catalysis (2009), 351, 1807-1812.


Probing the Mode of Asymmetric Induction of Biginelli Reaction Using Proline Ester Salts. 
Sohn, Jeong-Hun; Choi, Hyun-Moo; Lee, Sunjung; Joung, Seewon; Lee, Hee-Yoon. Eur. J. Org. Chem.(2009), 23, 3858-3862.


A facile total synthesis of (-)-frontalin, (-)-endo-brevicomin and (-)-exo-brevicomin through PtCl4 catalyzed hydroalkoxylation reaction.
Lee, Hee-Yoon; Jung, Yongsik; Moon, Hyunsik. Bull. Korean. Chem. Soc. (2009), 30, 771-772.


Development of non-peptidic farnesyltransferase inhibitors based on the Ca1a2 of Ras-CaaX. 
Lee, Hee-Yoon; Chun, Tae-Gyu; Choi, Hyun-Moo; Sohn, Jeong-Hun; Kwon, Byoung-Mog. Bull. Korean. Chem. Soc. (2009), 30, 291-292.


A facile total synthesis of all stereoisomers of tarchonanthuslactone and euscapholide from chiral epichlorohydrin. 
Lee, Hee-Yoon; Sampath, Vasu; Yoon, Yeokwon. Synlett (2009), 2, 249-252.





Initial Catalyst-Substrate Association Step in Enyne Metathesis Catalyzed by Grubbs Ruthenium Complex Probed by Time-Dependent Fluorescence Quenching. 
Sohn, Jeong-Hun; Kim, Kyung Hwan; Lee, Hee-Yoon; No, Zae Sung; Ihee, Hyotcherl. Journal of the American Chemical Society (2008), 130, 16506-16507.


Preparation of piperazinylpropylpyrazoles as dopamine D4 receptor antagonists. 
Kong, Jae Yang; Park, Woo-Kyu; Cho, Heeyeong; Jeong, Daeyoung; Choi, Gildon; Koh, Hun Yeong; Kim, Sang Hee; Pae, Ae Nim; Cho, Yong Seo; Cha, Joo Hwan; Choo, Hyunah; Chae, Sang Eun; Lee, Hee-Yoon. PCT Int. Appl. (2008), WO 2008108517 A2 20080912.


Cycloaddition reactions of trimethylenemethane diyls generated from alkynyl iodonium salts. 
Lee, Hee-Yoon; Yoon, Yeokwon; Lim, Yeon-Hee; Lee, Yonghan. Tetrahedron Letters (2008), 49, 5693-5696.


Structure-activity relationship studies of the chromosome segregation inhibitor, Incentrom A. 
Lee, Hee-Yoon; Jung, Yongsik; Kim, Wonyeob; Kim, JinHee; Suh, Min-Soo; Shin, Seung Koo; Yoon, Hye-Joo. Bioorganic & Medicinal Chemistry Letters (2008), 18, 4670-4674.


Chromen-based TNF-a converting enzyme (TACE) inhibitors: Design, synthesis, and biological evaluation. 
Chun, Kwangwoo; Park, Song-Kyu; Kim, Hwan Mook; Choi, Yongseok; Kim, Myung-Hwa; Park, Chun-Ho; Joe, Bo-Young; Chun, Tae Gyu; Choi, Hyun-Moo; Lee, Hee-Yoon; Hong, Sung Hee; Kim, Myung Sook; Nam, Ky-Youb; Han, Gyoonhee. Bioorganic & Bioorganic & Medicinal Chemistry (2008), 16, 530-535.





Solvent effect on sulfur ylide mediated epoxidation reaction. 
Lee, Hee-Yoon; Bae, Imhyuck; Min, Kyung-Hyun. Bulletin of the Korean Chemical Society (2007), 28, 2051-2055.


Modification of cap group in d-lactam-based histone deacetylase (HDAC) inhibitors. 
Kim, Hwan Mook; Hong, Sung Hee; Kim, Myung Sook; Lee, Chang Woo; Kang, Jong Soon; Lee, Kiho; Park, Song-Kyu; Han, Jeung Whan; Lee, Hee Yoon; Choi, Yongseok; Kwon, Ho Jeung; Han, Gyoonhee. Bioorganic & Medicinal Chemistry Letters (2007), 17, 6234-6238.


The stereoselective dimerization reaction of oxidopyrylium ions. 
Lee, Hee-Yoon; Kim, Hyoun Young; Kim, Byung Gyu; Kee, Jung Min. Synthesis (2007), 15, 2360-2364.


Structure-Activity Relationship Studies of a Series of Novel d-Lactam-Based Histone Deacetylase Inhibitors. 
Kim, Hwan Mook; Ryu, Dong-Kyu; Choi, Yongseok; Park, Bum Woo; Lee, Kiho; Han, Sang Bae; Lee, Chang-Woo; Kang, Moo-Rim; Kang, Jong Soon; Boovanahalli, Shanthaveerappa K.; Park, Song-Kyu; Han, Jung Whan; Chun, Tae-Gyu; Lee, Hee-Yoon; Nam, Ky-Youb; Choi, Eun Hyun; Han, Gyoonhee. Journal of Medicinal Chemistry (2007), 50, 2737-2741.


Triquinanes from linear ketones via trimethylenemethane diyls. 
Lee, Hee-Yoon; Kim, Won-Yeob; Lee, Sejin. Tetrahedron Letters (2007), 48, 1407-1410.





Synthesis, enzymatic inhibition, and cancer cell growth inhibition of novel d-lactam-based histone deacetylase (HDAC) inhibitors. 
Kim, Hwan Mook; Lee, Kiho; Park, Bum Woo; Ryu, Dong Kyu; Kim, Kangjeon; Lee, Chang Woo; Park, Song-Kyu; Han, Jung Whan; Lee, Hee Yoon; Lee, Hyun Yong; Han, Gyoonhee. Bioorganic & Medicinal Chemistry Letters (2006), 16, 4068-4070.


A highly selective k-opioid receptor agonist with low addictive potential and dependence liability. 
Park, Hee Sock; Lee, Hee Yoon; Kim, Yong Hae; Park, Jin Kyu; Zvartau, Edwin E.; Lee, Heeseung. Bioorganic & Medicinal Chemistry Letters (2006), 16, 3609-3613.


Selective catalytic activity of ball-shaped Pd@CM-48 nanocatalysts. 
Lee, Hee-Yoon; Ryu, Suyoung; Kang, Hongkyu; Jun, Young-wook; Cheon, Jinwoo. Chemical Communications (Cambridge, United Kingdom) (2006), 12, 1325-1327.


Gelastatins and their hydroxamates as dual functional inhibitors for TNF-a converting enzyme and matrix metalloproteinases: Synthesis, biological evaluation, and mechanism studies. 
Park, Song-Kyu; Han, Sang Bae; Lee, Kiho; Lee, Ho Jae; Kho, Yung Hee; Chun, Hyokon; Choi, Yongseok; Yang, Jae Young; Yoon, Yeo Dae; Lee, Chang-Woo; Kim, Hwan Mook; Choi, Hyun-Moo; Tae, Hyun Seop; Lee, Hee-Yoon; Nam, Ky-Youb; Han, Gyoonhee. Biochemical and Biophysical Research Communications (2006), 341, 627-634.





Practical halogenation of nucleosides using tetrabutylammonium peroxydisulfate. 
Sampath, Vasu; Jadhav, Vidyadhar; Lee, Hee Yoon; Kim, Yong Hae. Heterocycles (2005), 66, 51-56.


Controlled polymerization in mesoporous silica toward the design of organic-inorganic composite nanoporous materials. 
Choi, Minkee; Kleitz, Freddy; Liu, Dinan; Lee, Hee Yoon; Ahn, Wha-Seung; Ryoo, Ryong. Journal of the American Chemical Society (2005), 127, 1924-1932.


A facile tandem radical cyclization route to propellanes and its application to a total synthesis of modhephene. 
Lee, Hee-Yoon; Moon, Deuk Kyu; Bahn, Jong Soo. Tetrahedron Letters (2005), 46, 1455-1458.


A sequential cyclization route to spiroindanyl heterocycles through olefin metathesis and free radical reaction. 
Lee, Hee-Yoon; Moon, Deuk Kyu; Hahn, Mina. Bulletin of the Korean Chemical Society, (2005), 26, 229-230.


Facile Barton-McCombie deoxygenaiton of alcohols with tetrabutylammonium peoroxidisulfate. 
Park, Hee Sock; Lee, Hee Yoon; Kim, Yong Hae. Organic Letters, (2005), 7, 3187-3190.





Synthesis of 4-Alkyl-1(2H)-phthalazinones and 4-Alkyl-2,3-benzoxazin-1-ones via Ring Cleavage of 3-Substituted N-Alkylated-3-hydroxyisoindolin-1-ones. 
Chun, Tae Gyu; Kim, Kyung Soon; Lee, Sangku; Jeong, Tae-Sook; Lee, Hee-Yoon; Kim, Yong Hae; Lee, Woo Song. Department of Chemistry and School of Molecular Science, Korea Advanced Institute of Science and Technology, Daejeon, S. Korea. Synthetic Communications (2004), 34, 1301-1308.


Application of sulfur ylide mediated epoxidations in the asymmetric synthesis of b-hydroxy-d-lactones. Synthesis of a mevinic acid analogue and (+)-prelactone B. 
Aggarwal, Varinder K.; Bae, Imhyuck; Lee, Hee-Yoon. Tetrahedron (2004), 60, 9725-9733.


A tandem radical cyclization route to tricyclo[4.3.n.01,5]alkanes 
Lee, Hee-Yoon; Lee, Sejin; Kim, Byung Gyu; Bahn, Jong Soo. Tetrahedron Letters (2004), 45, 7225-7229.


Selective reduction of the nitro-group using Co2(CO)8-H2O 
Lee, Hee-Yoon; An, Mihyun. Bulletin of the Korean Chemical Society, (2004), 25, 1717-1719.





Synthesis of multi-substituted pyrazoles utilizing the N-alkylated 3-hydroxy-3-propargyl- or allenylisoindolines. 
Choi, Yong Hyun; Kim, Kyung Soon; Lee, Sangku; Jeong, Tae-Sook; Lee, Hee-Yoon; Kim, Yong Hae; Lee, Woo Song. Heterocycles (2003), 60, 2499-2510.


Sulfur-ylide-mediated synthesis of functionalized and trisubstituted epoxides with high enantioselectivity; application to the synthesis of CDP-840. 
Aggarwal, Varinder K.; Bae, Imhyuck; Lee, Hee-Yoon; Richardson, Jeffery; Williams, David T. Angewandte Chemie, International Edition (2003), 42, 3274-3278.


Ordered mesoporous carbon molecular sieves with functionalized surfaces. 
Jun, Shinae; Choi, Minkee; Ryu, Suyoung; Lee, Hee-Yoon; Ryoo, Ryong. Studies in Surface Science and Catalysis (2003), 146(Nanotechnology in Mesostructured Materials), 37-40.


Triquinanes from Linear Alkylidene Carbenes via Trimethylenemethane Diyls. 
Lee, Hee-Yoon; Kim, Yeonjoon. Journal of the American Chemical Society (2003), 125, 10156-10157.


A facile synthesis of 1,2-oxaphospholenes and stereoselective conversion into oxaphospholanes. 
Hah, Jung Hwan; Lee, Bum Sung; Lee, Shi Yong; Lee, Hee-Yoon. Tetrahedron Letters (2003), 44, 5811-5814.


A practical total synthesis of gelastatins. 
Lee, Hee-Yoon; Tae, Hyun Seop; Kim, Byung Gyu; Choi, Hyun-Moo. Tetrahedron Letters (2003), 44, 5803-5806.


Studies on reductive Pauson-Khand reaction using cobaltcarbonyls with water. 
Lee, Hee-Yoon; An, Mihyun; Sohn, Jeong-Hun. Bulletin of the Korean Chemical Society (2003), 24, 539-540.


A Stereoselective Enyne Cross Metathesis. 
Lee, Hee-Yoon; Kim, Byung Gyu; Snapper, Marc L. Organic Letters (2003), 5, 1855-1858.


Selective 1,4-reduction of unsaturated carbonyl compounds using Co2(CO)8-H2O. 
Lee, Hee-Yoon; An, Mihyun. Tetrahedron Letters (2003), 44, 2775-2778.


One-pot three-component tandem metathesis/Diels-Alder reaction 
Lee Hee-Yoon; Kim Hyoun Young; Tae Hyunsup; Kim Byung Gyu; Lee Jaeyoung. Organic letters (2003), 5, 3439-42.





Preparation of 1-aryl-4-[(3-phenyl-4,5-dihydro-5-isoxazolyl)alkyl]piperazines and analogs as dopamine D3 and D4 receptor antagonists.

Koh, Hun Yeong; Choi, Kyung; Cho, Yong Seo; Pae, Ae Nim; Kong, Jae Yang; Jeong, Dae Young; Jung, Sun Ho; Jung, Ji Young; Lee, Hee-Yoon. Brit. UK Pat. Appl. (2002), 46.


Development of tripeptidyl farnesyltransferase inhibitors. 
Lee, Hee-Yoon; Sohn, Jeong-Hun; Kwon, Byoung-Mog. Bioorganic & Medicinal Chemistry Letters (2002), 12(12), 1599-1602.


Design and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands. 
Cha, Mi Young; Choi, Byung Chul; Kang, Kyung Ho; Pae, Ae Nim; Choi, Kung Il; Cho, Yong Seo; Koh, Hun Yeong; Lee, Hee-Yoon; Jung, Daeyoung; Kong, Jae Yang. Bioorganic & Medicinal Chemistry Letters (2002), 12(10), 1327-1330.





A stereoselective synthesis of 1-acetyl-2-aminomethylcyclopropanes from allylsulfonamides and phenyl(alkynyl)iodonium salts. 
Lee, Hee-Yoon; Lee, Yong-Han. Synlett (2001), (10), 1656-1658.





A Facile Construction of the Quadranoid Skeleton: Application to the Total Synthesis of ( ± )-Suberosenone. 
Lee, Hee-Yoon; Kim, Byung Gyu. Organic Letters (2000), 2(13), 1951-1953.


A facile synthesis of DL-modhephene. 
Lee, Hee-Yoon; Kim, Deog-II; Kim, Sunggak. Bulletin of the Korean Chemical Society (1999), 20(3), 269-270.


Design and synthesis of N-alkylated saccharins as selective a -1A adrenergic receptor antagonists. 
Nerenberg, Jennie B.; Erb, Jill M.; Thompson, Wayne J.; Lee, Hee-Yoon; Guare, James P.; Munson, Peter M.; Bergman, Jeffrey M.; Huff, Joel R.; Broten, Theodore P.; Chang, Raymond S. L.; Chen, Tsing B.; O'Malley, Stacey; Schorn, Terry W.; Scott, Ann L. Bioorganic & Medicinal Chemistry Letters (1998), 8(18), 2467-2472.


Total synthesis of a -cedrene: a new strategy utilizing N-aziridinylimine radical chemistry. 
Lee, Hee-Yoon; Lee, Sejin; Kim, Deogil; Kim, Byung Kyu; Bahn, Jong So; Kim, Sunggak. Tetrahedron Letters (1998), 39(42), 7713-7716.


Preparation of benzisothiazolones and analogs as a 1C-adrenergic receptor antagonists. 
Huff, Joel R.; Lee, Hee-yoon; Nerenberg, Jennie B.; Thompson, Wayne J.; Bell , Ian M. (Merck and Co., Inc., USA ). U.S. (1998), 57 pp., Cont.-in-part of U. S. Ser. No. 229,276, abandoned.


The Total Synthesis of a Natural Cardenolide: (+)-Digitoxigenin. 
Stork, Gilbert; West, Fred; Lee, Hee Yoon; Isaacs, Richard C. A.; Manabe, Shino. Journal of the American Chemical Society (1996), 118(43), 10660-10661.


Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation. 
Ghosh, Arun K.; Kincaid, John F.; Walters, D. Eric; Chen, Yan; Chaudhuri, Narayan C.; Thompson, Wayne J.; Culberson, Chris; Fitzgerald, Paula M. D.; Lee, Hee Yoon; et al. Journal of Medicinal Chemistry (1996), 39(17), 3278-3290.


Tandem radical cyclization reaction of N-aziridinyl imines to [3.3.3]propellanes: formal total syntheses of dl-modhephene. 
Lee, Hee-Yoon; Kim, Deog-Il; Kim, Sunggak. Chemical Communications ( Cambridge ) (1996), (13), 1539-1540.


Preparation of heterocycles as a 1c adrenergic receptor antagonists. 
Huff, Joel R.; Lee, Hee-Yoon; Nerenberg, Jennie B.; Thompson, Wayne J. PCT Int. Appl. (1995), 209.


Process for the preparation of oxiranes, aziridines, or cyclopropanes. 
Aggarwal, Varinder Kumar; Abdel-Rahman, Hesham Nimer Hasan; Lee, Hee Yoon. PCT Int. Appl. (1995), 36.


Preparation of piperazine derivatives as HIV protease inhibitors. 
Kim, Byeong Moon; Vacca, Joseph P.; Ghosh, Arun K.; Guare, James P., Jr.; Huff, Joel R.; Hungate, Randall W.; Lee, Hee Yoon; Thompson, Wayne J. PCT Int. Appl. (1994), 82.


The Development of Cyclic Sulfolanes as Novel and High-Affinity P2 Ligands for HIV-1 Protease Inhibitors. 
Ghosh, Arun K.; Lee, Hee Yoon; Thompson, Wayne J.; Culberson, Chris; Holloway, M. Katharine; McKee, Sean P.; Munson, Peter M.; Duong, Tien T.; Smith, Anthony M.; et al. Journal of Medicinal Chemistry (1994), 37(8), 1177-88.


Novel Catalytic Cycle for the Synthesis of Epoxides from Aldehydes and Sulfur Ylides Mediated by Catalytic Quantities of Sulfides and Rh2(OAc)4. 
Aggarwal, Varinder K.; Abdel-Rahman, Hesham; Jones, Ray V. H.; Lee, Hee Yoon; Reid, Bruce D. Journal of the American Chemical Society (1994), 116(13), 5973-4.


A short synthesis of 3(R)-hydroxy-2(R)-isopropyltetrahydrothiophene: a precursor to a high-affinity P2-ligand of HIV-1 protease inhibitors. 
Kim, B. Moon; Lee, Hee Yoon; Munson, Peter M.; Guare, James P.; McDonough, Colleen. Tetrahedron Letters (1993), 34(41), 6517-20.


Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands. 
Ghosh, Arun K.; Thompson, Wayne J.; Holloway, M. Katharine; McKee, Sean P.; Duong, Tien T.; Lee, Hee Yoon; Munson, Peter M.; Smith, Anthony M.; Wai, Jenny M.; et al. Journal of Medicinal Chemistry (1993), 36(16), 2300-10.


Preparation of decahydroisoquinolinecarboxamides as HIV protease inhibitors. 
Thompson, Wayne J.; Ghosh, Arun K.; Lee, Hee Yoon; Huff, Joel R. Eur. Pat. Appl. (1993), 30 pp.


Cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors. 
Ghosh, Arun K.; Thompson, Wayne J.; Lee, Hee Yoon; McKee, Sean P.; Munson, Peter M.; Duong, Tien T.; Darke, Paul L.; Zugay, Joan A.; Emini, Emilio A.; et al. Journal of Medicinal Chemistry (1993), 36(7), 924-7.


3'-Tetrahydrofuranylglycine as a novel, unnatural amino acid surrogate for asparagine in the design of inhibitors of the HIV protease. 
Thompson, Wayne J.; Ghosh, Arun K.; Holloway, M. Katharine; Lee, Hee Yoon; Munson, Peter M.; Schwering, John E.; Wai, Jenny; Darke, Paul L.; Zugay, Joan; et al. Journal of the American Chemical Society (1993), 115(2), 801-3.


A facile and enantiospecific synthesis of 2(S)- and 2(R)-[1'(S)-azido-2-phenylethyl]oxirane. 
Ghosh, Arun K.; McKee, Sean P.; Lee, Hee Yoon; Thompson, Wayne. Journal of the Chemical Society, Chemical Communications (1992), (3), 273-4.


Studies on tumor promoters. 7. The synthesis of a potentially general precursor of the tiglianes, daphnanes, and ingenanes. 
Wender, Paul A.; Lee, Hee Yoon; Wilhelm, Robert S.; Williams, Peter D. Journal of the American Chemical Society (1989), 111(24), 8954-7.


Studies on tumor promoters. 8. The synthesis of phorbol. 
Wender, Paul A.; Kogen, Hiroshi; Lee, Hee Yoon; Munger, John D., Jr.; Wilhelm, Robert S.; Williams, Peter D. Journal of the American Chemical Society (1989), 111(24), 8957-8.


Synthetic and pharmacological studies on tumor promoters: Synthesis of phorbol and phorbol analogs. 
Lee, Hee Yoon. Stanford Univ. , Stanford , CA , USA . Avail. Univ. Microfilms Int., Order No. DA8826181. (1988), 256 pp.


Studies on tumor promoters: the first synthesis of the phorbol skeleton. 
Wender, Paul A.; Keenan, Richard M.; Lee, Hee Yoon. Journal of the American Chemical Society (1987), 109(14), 4390-2.


Tumor promotion: pharmacological and synthetic studies. 
Wender, Paul A.; Koehler, Konrad F.; Wilhelm, Robert S.; Williams, Peter D.; Keenan, Richard M.; Lee, Hee Yoon. Studies in Organic Chemistry ( Amsterdam ) (1986), 25(New Synth. Methodol. Funct. Interesting Compd.), 163-82.


Studies in remote functionalization. (I). Synthesis and spectroscopic studies of 3 a , 5 a -cyclosteroidal substrates. 
Lee, Eun; Park, Sang Kyu; Lee, Hee-Yoon; Kim, Wan Joo. Bulletin of the Korean Chemical Society (1981), 2(3), 105-12.

Organic Synthesis & Medicinal Chemistry Lab

Address: Department of Chemistry(E6-4), 291 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea

TEL: +82-42-350-2875